Expression of circulating micro-RNAs in hypertensive patients with left ventricular hypertrophy
نویسندگان
چکیده
Background Left ventricular hypertrophy (LVH) is a common presentation among hypertensive patients. Micro-RNAs (miRNAs) have been proven to show reproducible dysregulations in hypertrophied cardiac tissues. Three miRNAs, miR-133, miR-155, and miR-195 were used in the study to elucidate the miRNA expression anomaly in heart diseases. MiR-133 and miR-195 have been reported as two highly expressed miRNAs in normal mouse heart tissue. The aim of this study is to observe the relationship of the levels of circulating miR-133, miR-155 and miR-195, with the phenotype of cardiac hypertrophy among LVH patients and normal controls.
منابع مشابه
Association between cytokines and two circulating micro-RNAs and development of premature ventricular contractions-induced cardiomyopathy
Objective(s): Recent progress in understanding the pathogenesis of premature ventricular contraction (PVC)-induced cardiomyopathy (PIC) has suggested a key role for inflammation. The aim of this study was to evaluate the expression of messenger RNAs (mRNAs) and the protein production of interleukin-6 (IL-6), IL-10, tumor necrosis factor alpha (TNF-α) and interferon-γ (...
متن کاملEffect of Carvacrol on Catalase Activity and mRNA Expression Following Left Ventricular Hypertrophy in Rats
Background and Aims: Cardiac hypertrophy is a compensatory augmentation response of the heart due to pressure overload that can lead to heart failure. Carvacrol is considered as the major compound of many plants, that possesses strong antioxidant properties. The present study aimed to evaluate effect of carvacrol on catalase activity and mRNA expression following left ventricular hypertrop...
متن کاملElectrocardiographic left ventricular hypertrophy is not associated with increased in-hospital adverse events in patients experiencing first non-ST segment elevation myocardial infarction: A single center study
Background: There is conflicting data about prognostic implication of electrocardiographic (ECG) left ventricular hypertrophy (LVH) in patients with first non- ST-segment elevation myocardial infarction (NSTEMI). We aimed to examine the association of left ventricular hypertrophy (LVH) on admission electrocardiogram with adverse outcomes in patients with NSTEMI. Methods: In the present study, ...
متن کاملThe effect of high-intensity interval training on the expression of protein kinase B (Akt gene) in the left ventricle of male rats with type 2 diabetes
Introduction: The term diabetes heart in diabetic patients includes pathologic left ventricular hypertrophy. Stimulation of the signaling and molecular pathways of cardiac myocardial remodeling through exercise in this regard can be considered as a therapeutic strategy for physiological development of the left ventricle. In the present study, the effect of 8 weeks of high intensity interval tra...
متن کاملResveratrol Suppresses Cardiac Renin Angiotensin System in the Late Phase of Left Ventricular Hypertrophy
Background and objectives: Resveratrol(3,5,4′-trihydroxy-trans-stilbene) is a natural polyphenole phytoalexin which exerts potential cardioprotective effects, but the cellular and molecular mechanisms responsible for these effects are still unknown. Cardiac renin angiotensin system (RAS) over-activation plays an important role in pathogenesis of left ventricula...
متن کامل